CI simulations The Combination Index estimated for each effect value is given in this table. Analysis of drug interactions.Ī new experiment will then be created and the drug data imported. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, graphics packages etc. The large majority of combination regimens are being developed empirically and there are few experimental studies designed to explore thoroughly different drug combinations, using appropriate methods of analysis.Īlready used in hundreds of academic labs and pharmaceutical companies, CalcuSyn is indispensable for the study of drug mixtures. This approximates to a normal distribution for small values of SE Dm but this assumption may not be valid as the uncertainty in Dm increases. A powerful and straightforward combined drug effects analyzer which also enables you to import and export information to various file formats. Double-click on Experiment Details to enter the experiment properties.
It must be typed exactly as shown although the case of the letters is not crucial. The summary table gives a one-line summary of the drug parameters for each component and for the combination drug. Download CalcuSynĭouble-click on Raw Data to open the raw data grid to enter drug data. A combination can be studied by combining the two agents in various different ways, such as simultaneous or sequential combination schedules. For two drug combinations, we may define from Eq. Graphs The export graph dialog opens when you select File Export from within a graph window. Whether synergy is treatment schedule dependent or combination ratio dependent? If is not found in the file an error message will be produced. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. Manual and Software, Biosoft, Cambridge, U.K., Chou, T.-C. and antagonism, respectively (Source: CalcuSyn manual, Biosoft, ). combination-index data generated by CalcuSyn software analyses. 年1月23日 CalcuSyn is a software tool whose main purpose is to aid individuals in analyzing mixed drug treatments, a more and more used practice in.
A comprehensive manual is supplied with the software and there is a detailed Help file. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, and graphics packages. CalcuSyn Version 2.0 has Undo and Redo tools. So you have to make sure that the r values you get. Compusyn makes very easy your drug combined effect data analysis, but the main pre-requisite is conformity of your crude data to mass action law.
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